Research Progress on the Relationship between Obesity-Inflammation-Aromatase Axis and Male Infertility

Figure 2

Signal transduction pathway of aromatase expression regulated by PGE2 through PGT. PGT is a trans-membrane domain transporter that carries extracellular PGE2 into cytoplasm, which activates the CAMP/PKA/CREB pathway by binding to its receptors EP2 and EP4, thus resulting in enhanced interaction between CREB, p300, and aromatase promoter I.3/II. PGE2 also decreased the amounts of BRCA1 and inhibited the interaction of BRCA1 and aromatase promoter I.3/II; then, CYP19 transcription and aromatase activity are enhanced ultimately.