Genomic and Transcriptome Analysis to Identify the Role of the mTOR Pathway in Kidney Renal Clear Cell Carcinoma and Its Potential Therapeutic Significance

Figure 4

(a) Clustering of gene data from the TCGA database reveals three clusters. Upregulation of mTOR pathway genes was demonstrated in cluster1, and downregulation of mTOR pathway genes was demonstrated in cluster3. In cluster2, mTOR pathway genes were affected the least. The percentage of patients whose genes were altered is provided, showing the high frequency of changes in mTOR pathway genes. (b) The Violin plot shows the enrichment score of the three clusters. The plot shows the enrichment scores of the three clusters, from high to low, as cluster1, then cluster2, followed by cluster3. (c) The survival curves of the three clusters are shown in the plot. Survival in cluster1 is higher than that in cluster2, and survival in cluster2 is higher than that in cluster3. (d) Heat map showing the correlation between mTOR scores and the clinicopathological characteristics of KIRC patients. , , and .

(a)

(b)

(c)

(d)