Genomic and Transcriptome Analysis to Identify the Role of the mTOR Pathway in Kidney Renal Clear Cell Carcinoma and Its Potential Therapeutic Significance

Figure 6

(a) The expression of 40 mTOR pathway genes in KIRC patients. In the color bar on the right side, blue represents upregulation and yellow represents downregulation. N (green) is the normal sample, T (red) is the tumor sample. , , . (b) The plot shows the hazard ratio (HR) analysis with 95% confidence intervals (CI) and values for the mTOR pathway genes. (c) The plot shows the result of the coexpression analysis of 40 mTOR pathway genes. Many of them were correlated in KIRC tissues. (d) The LASSO coefficient profiles of mTOR pathway genes in KIRC. (e) Five genes were selected by LASSO Cox regression analysis. (j) The survival curve was obtained based on this model. Blue and yellow correspond, respectively, to the high-risk group and the low-risk group. (f–i) ROC curves of 3, 5, 7, and 10 years; the AUCs of the curves are 0.692, 0.725, 0.778, and 0.794, respectively. (k) The correlation of five selected genes and the clinicopathological characteristics in two groups. The color bar shows the expression of the genes. Blue represents upregulation, and yellow represents downregulation. , , .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)