Anti-Interleukin-16 Neutralizing Antibody Treatment Alleviates Sepsis-Induced Cardiac Injury and Dysfunction via the Nuclear Factor Erythroid-2 Related Factor 2 Pathway in Mice

Figure 3

Effects of anti-IL-16 nAb on cardiac injury and function in septic mice. (a) Survival rates during the 8-day follow-up in each group (log-rank test). (b–d) Serum levels of oxidative stress markers in the four groups (two-way ANOVA). (e–h) Cardiac structure and function were determined by echocardiography (nonparametric test). -10 in each group. vs. the IgG saline group. ^# vs. the IgG LPS group. nAb: anti-IL-16 neutralizing antibody; LPS: lipopolysaccharide; LDH: lactate dehydrogenase; CK-MB: creatine kinase myocardial bound; cTnT: cardiac troponin T; LVEDD: left ventricular end-diastolic diameter; LVESD: left ventricular end-systolic diameter; LVEF: left ventricular ejection fraction; FS: fractional shortening.

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