Anti-Interleukin-16 Neutralizing Antibody Treatment Alleviates Sepsis-Induced Cardiac Injury and Dysfunction via the Nuclear Factor Erythroid-2 Related Factor 2 Pathway in Mice

Figure 6

Effects of CPUY192018 on cardiac injury in septic mice. (a) Survival rates were measured for each group (log-rank test). (b–d) Serum levels of cardiac injury markers, including CK-MB, LDH, and cTnT, were measured (two-way ANOVA). (e–h) Cardiac structure and function in each group were measured (two-way ANOVA). in each group. vs. the nAb DMSO+LPS group. LPS: lipopolysaccharide; DMSO: dimethyl sulfoxide; CPU: CPUY192018; nAb: anti-IL-16 neutralizing antibody; LDH: lactate dehydrogenase; CK-MB: creatine kinase myocardial bound; cTnT: cardiac troponin T; LVEDD: left ventricular end-diastolic diameter; LVESD: left ventricular end-systolic diameter; LVEF: left ventricular ejection fraction; FS: fractional shortening.

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