RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation

Figure 2

Cardiac dysfunction, CaMKIIδ activity, and RIPK3 expression are augmented in db/db mice. (a–c) In db/db and its wild-type mice, cardiac function was assessed by echocardiography and EF, FS, and E/A were calculated. (d) In db/db and its wild-type mice, the mRNA levels of CaMKIIδA, CaMKIIδB, and CaMKIIδC of the myocardium were detected by quantitative real-time PCR. 18S was serviced as a housekeeping mRNA. (e) In db/db and its wild-type mice, RIPK3 protein expression was quantified by western blot. GAPDH was used as a loading control. ^& and ^&&, significantly from WT. .

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