Research Article
RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation
Figure 7
I1PP1 overexpression inhibits oxidation and phosphorylation of CaMKII and improves myocardial mitochondrial ultrastructure in DCM mice. (a, b) Expression of CaMKII oxidation (ox-CaMKII), CaMKII phosphorylation (p-CaMKII), and total CaMKII was quantified by western blot. GAPDH was used as a loading control. (c) Myocardial mitochondrial ultrastructure was examined with a transmission electron microscope. Scale bars: 2 μm (upper) and 0.5 μm (lower), respectively. and #; NS: no significance. .
(a) |
(b) |
(c) |