The Association of Polymorphisms in Nrf2 and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma

Table 4

Haplotype analysis of GSTP1 rs1695 and rs1138272 polymorphisms in patients with ccRCC.

Genotype			Haplotype frequencies
	rs1695	rs1138272	ccRCC patients, %	Controls, %	OR (95% CI)^a	value
GSTP1A^d	A	C	56	64	1.00^b
GSTP1B^e	G	C	38	30	1.50 (1.10–2.05)	0.012
GSTP1C^f	G	T	5	3	3.50 (1.49–8.22)	0.004
GSTP1D^g	A	T	1	3	0.00 (N/A^c)	1.000
	Global haplotype association value: <0.001

^aOR: odds ratio adjusted for age, gender, BMI, pack-years, and hypertension; CI: confidence interval; ^breference group; ^cN/A: not applicable; ^dGSTP1A genotype consisting of Ile105 and Ala114; ^eGSTP1B genotype consisting of Val105 and Ala114; ^fGSTP1C genotype consisting of Val105 and Val114; ^gGSTP1D genotype consisting of Ile105 and Val114.