The Association of Polymorphisms in Nrf2 and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma

Table 5

Nrf2, SOD2, GPX1, and GSTP1 genotype distribution among living and deceased ccRCC patients.

Genotype	Living patients, (%)	Deceased patients, (%)	value
Nrf2 (rs6721961)
C/C^a	99 (76)	59 (75)
C/A and A/A^b	31 (24)	19 (25)	0.530
SOD2 (rs4880)
Ala/Ala^c	31 (24)	12 (15)
Ala/Val and Val/Val^d	101 (76)	68 (85)	0.093
GPX1 (rs1050450)
Pro/Pro^e	57 (43)	46 (57)
Pro/Leu and Leu/Leu^f	77 (57)	34 (43)	0.024
GSTP1 (rs1695 and rs1138272)
(Ile/Ile) (Ala/Ala)^g	41 (31)	12 (15)
(Ala/Ala)(Pro/Leu+Leu/Leu); (Ala/Val+Val/Val)(Pro/Pro); (Ala/Val+Val/Val)(Pro/Leu+Leu/Leu)^h	93 (69)	68 (85)	0.007

^aC/C: carriers of both referent alleles; ^bC/A and A/A: carriers of at least one variant allele; ^cAla/Ala: carriers of both referent alleles; ^dAla/Val and Val/Val: carriers of at least one variant allele; ^ePro/Pro: carriers of both referent alleles; ^f Pro/Leu and Leu/Leu: carriers of at least one variant allele; ^g(Ile/Ile) (Ala/Ala): carriers of both referent alleles for rs1695 and rs1138272; ^hcarriers of at least one variant allele for either rs1695 or rs1138272.