Novel Role of miR-18a-5p and Galanin in Rat Lung Ischemia Reperfusion-Mediated Response

Figure 2

High-throughput analysis of differentially expressed miRNA in NC vs. IR rat models. (a) Pearson’s correlation analysis between all six set of samples (NC 1-3, IR 1-3) used for high-throughput sequencing of miRNAs. (b) Volcano plot showing the distribution of miRNAs that are significantly upregulated (red) and downregulated (green) or showed no change (blue) on ischemia reperfusion (IR) as compared to sham-operated (NC) rat models. (c) Hierarchical clustering of miRNAs vs. samples where rows represent the clustering of miRNAs and columns represent the clustering of samples. As the miRNA abundance ratio changes from small to large, the heat map color shows a corresponding red-white-blue change.

(a)

(b)

(c)