Metabolomics Analysis of the Development of Sepsis and Potential Biomarkers of Sepsis-Induced Acute Kidney Injury

Table 1

Differential metabolic pathways (CT vs. LPS2). The results of enriched compounds after screening and metabolic metabolic pathway enrichment analysis (MPEA) between CT and LPS2 groups are summarized in this table.

	Total in pathway	Expected	Hits	Raw P		Holm P	FDR	Impact	Enriched compounds
Arginine and proline metabolism	44	0.65906	5	0.000338	7.9912	0.027413	0.027413	0.18368	Citrulline; Fumaric acid; L-Arginine; L-Proline; Urea
Aminoacyl-tRNA biosynthesis	67	1.0036	5	0.002405	6.0301	0.19243	0.097416	0.10415	L-Alanine; L-Arginine; L-Asparagine; L-Cysteine; L-Proline
Alanine, aspartate, and glutamate metabolism	24	0.35949	3	0.004792	5.3407	0.3786	0.11482	0.04	Fumaric acid; L-Alanine; L-Asparagine
Taurine and hypotaurine metabolism	8	0.11983	2	0.00567	5.1726	0.44225	0.11482	0.5	L-Cysteine; Taurine
Pantothenate and CoA biosynthesis	15	0.22468	2	0.019959	3.9141	1	0.32333	0.07692	L-Cysteine; Uracil

Holm: Holm-Bonferroni method; FDR: false discovery rate.