Pathophysiology and Therapeutic Potential of NADPH Oxidases in Ischemic Stroke-Induced Oxidative Stress

Figure 1

Schematic illustration of the activation mechanism of NOX2. NOX2 activation is mediated by the assembly of four cytoplasmic proteins (p67phox, p40phox, p47phox, and Rac2) with two transmembrane proteins (gp91phox and p22phox), and the activated NOX2 catalyzes oxygen to superoxide through NADPH.