Pathophysiology and Therapeutic Potential of NADPH Oxidases in Ischemic Stroke-Induced Oxidative Stress

Figure 3

Schematic illustration of the activation mechanism of NOX5. NOX5 activation requires calcium ions by binding N-terminal EF-hand motifs to produce superoxides. The binding of Hsp90, caveolin-1, and tyrosine kinase c-Abl to NOX5 can regulate NOX5 activity and ROS production.