Pathophysiology and Therapeutic Potential of NADPH Oxidases in Ischemic Stroke-Induced Oxidative Stress

Table 2

The role of NOX inhibitors in animal models of ischemic stroke.

NOX inhibitors	Pharmacological mechanism	Tissues or cells	Ischemia time	Reperfusion time	Effect	References
VAS2870	Inhibit NOX1, NOX2, NOX4, and NOX5	Brain sections of mice	12 h	/	+	Kleinschnitz, C (2010) [50]
		Rat hippocampal brain slice	0.25 h	2 h	+	Casas, A.I (2017) [22]
M13	Inhibit NOX1 and NOX4	A human in vitro model of BBB	6 h	24 h	+	Dao, V.T (2020) [28]
		Primary culture of HBMECs	6 h	24 h	+	Casas, A.I (2019) [20]
GKT136901	Inhibit NOX1, NOX2, NOX4, and NOX5	Primary culture of HBMECs	6 h	24 h	+	Casas, A.I (2017) [22]
		Rat hippocampal brain slice	0.25 h	2 h	+	Casas, A.I (2017) [22]
ML090	Inhibit NOX1, NOX4, and NOX5	Primary culture of HBMECs	6 h	24 h	+	Casas, A.I (2019) [20]
ML171	Inhibit NOX1, NOX4, and NOX5	A human in vitro model of BBB	6 h	24 h	+	Casas, A.I (2019) [20]

Abbreviations: HBMECs: human brain microvascular endothelial cells; BBB: blood-brain barrier. +, brain protection/neuroprotection; -, brain damage/neurological dysfunction.