Protective Effects and Mechanisms of Recombinant Human Glutathione Peroxidase 4 on Isoproterenol-Induced Myocardial Ischemia Injury

<div>rhGPx4 reduces oxidative stress injury in heart tissue. (a) Representative images of DHE staining of the heart tissue (fluorescence microscope, ×200) and DHE fluorescence intensity. (b) The effects of rhGPx4 on MDA levels in the serum and heart tissue. (c) Representative western blot bands of Nrf2, Lamin B, HO-1, and <i>β</i>-actin. The expression levels of (d) Nrf2 (Nucleus) and (e) HO-1 in the heart tissue. 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27V0H384Z"></path></g></svg> vs. ISO.</div>

Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Protective Effects and Mechanisms of Recombinant Human Glutathione Peroxidase 4 on Isoproterenol-Induced Myocardial Ischemia Injury 