Protective Effects and Mechanisms of Recombinant Human Glutathione Peroxidase 4 on Isoproterenol-Induced Myocardial Ischemia Injury

Figure 9

Amino acid sequence and structure of rhGPx4. (a) Overall structure and catalytic center of rhGPx4 (PDB: 6ELW). The catalytic tetrads consisting of Sec, Gln, Trp, and Asn are labeled. (b) Amino acid sequence of rhGPx4. The catalytic tetrads are marked. (c) Electrostatic potential surface representation of rhGPx4. The catalytic center is circled. Red indicates a negative electrostatic potential, and blue indicates a positive electrostatic potential. Cartoon representations were generated in PyMol.

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