α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells

Figure 1

LA inhibits proliferation, induces apoptosis, and inhibits shift rate in lung cancer cells. (a) Chemical structure of LA. (b) Lung cancer cell lines were treated with different doses of LA for 24 h or 48 h. Cell proliferation was examined by CCK8 assay, and the IC50 values of LA were calculated by GraphPad (Prism) software. (c) Cell morphology were captured under the bright field of microscope exposed to different doses of LA. (d) LA inhibits the shift of A549and PC9 cells in a time-dependent manner. (e) The cells were exposed to 1.5 mM of LA for 24 h and 48 h, and then, Annexin/PI double staining was used to evaluate the apoptotic rates. Results were shown as the The symbol indicates ; indicates .

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