HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib

<div>HCC827 GR cell line was established. (a) Gefitinib sensitivity between parental HCC827 cells and HCC827 GR cells was compared. Cell viability was measured by MTT assay. 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(b) Morphological changes from parental HCC827 cells to HCC827 GR cells. Original magnification, ×200.</div>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib 