HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib

<div>Effect of YC-1 on cell viability of parental HCC827 cells and HCC827 GR cells. (a) Cells were exposed to 10, 20, 30, 40, 50, and 60 <i>μ</i>M YC-1 and 0.066% DMSO for 24 h. YC-1 concentrations higher than 40 <i>μ</i>M were not able to further inhibit the viability of HCC827 and HCC827GR cells. (b) Cells were treated with 40 <i>μ</i>M YC-1 for different incubation times, and an increase of the YC-1 exposure time resulted in a decrease of the cell viability. Cell viability was measured by MTT assay. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib 