HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib

<div>MTT assay in parental HCC827 cells and HCC827 GR cells with different treatments. Cell viability of cells with different treatments (blank control, YC-1, gefitinib, YC-1, and gefitinib combined, for 16 h and 28 h) was evaluated by MTT assay. The concentration of YC-1 was 40 <i>μ</i>M, and the final concentration of gefitinib was 20 nM. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib 