HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib

<div>MET amplification detected by ddPCR CNV assay. In the process of the HCC827 GR cell line established, MET levels from parental HCC827 cell to HCC827 GR cell (the gefitinib concentration was increased gradually from 0 <i>μ</i>M to 1 <i>μ</i>M) were shown. MET levels of HCC827 GR cell with different treatment (blank control, YC-1, gefitinib, and YC-1 and gefitinib combined for 16 h and 28 h) were shown too. The concentration of YC-1 was 40 <i>μ</i>M, and the final concentration of gefitinib was 20 nM. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: HIF-1 Inhibitor YC-1 Reverses the Acquired Resistance of EGFR-Mutant HCC827 Cell Line with MET Amplification to Gefitinib 