Circular RNAs: Novel Players in the Oxidative Stress-Mediated Pathologies, Biomarkers, and Therapeutic Targets

Table 1

The effect of circRNAs on OxS in the cardiovascular system.

circRNA	Mediators	Effect	Disease	Model	Clinical application	Ref
circNCX1	miR-133a-3p	Mediates the ROS-induced apoptosis in ischemic myocardial injury	Ischemic heart disease	H9c2 cell line (H2O2 treated), neonatal cardiomyocytes and mouse model of myocardial infarction	Target for antioxidant therapy	[57]
circANXA2	miR-133 BCL2	Same as circNCX1	Ischemic heart disease	H9c2 cell line (H2O2 treated)	Target for antioxidant therapy	[58]
circHIPK3	miR-29a and IFG1	Suppresses the OxS-induced apoptosis	Ischemic heart disease	CMVECs	Antioxidant therapy	[59]
circFoxO3	Antistress proteins FAK and HIF1a	Mediates oxidative stress-induced senescence	Cardiomyopathy	Cell culture and mouse model	Target for antioxidant therapy	[60]
circITCH	miR-330-5p	Reduces the mitochondrial and cellular ROS production	Doxorubicin-induced cardiomyopathy	Cell culture, mouse model	Antioxidant therapy	[61]
Amotl1	AKT and PKD1 proteins	Mediates the activity of OxS	Doxorubicin-induced cardiomyopathy	Cell culture, mouse model	Antioxidant therapy	[62]
circANRIL	NA	Inhibits SOD activity and reduces atherosclerosis-associated cell damage	Atherosclerosis	In vitro EC derived from Aorat of an atherosclerotic rat model	Antioxidant therapy	[68]
circRNA ZNF609	miR-615-5p-MEF2A	Reduces OxS-associated retinal vessel loss and pathological angiogenesis	Vascular endothelial dysfunction	HUVRCs; OIR mouse model	Target for antioxidant therapy	[69]

NCX1: sodium/calcium exchanger 1; circANRIL: circular antisense noncoding RNA in the INK4 locus; PDK: phosphoinositide-dependent kinase.