Circular RNAs: Novel Players in the Oxidative Stress-Mediated Pathologies, Biomarkers, and Therapeutic Targets

Table 4

The potential for the use of circRNAs as diagnostic and therapeutic tools for OxS-induced nervous system diseases.

circRNA	Mediators	Effect	Disease	Model	Clinical application	Ref
mmu_circRNA_34132; mmu_circRNA_017077; mmu_circRNA_015216	miR-27 and miR-34a	Mediates the protective effect of Nrf2	PD	Substantia nigra and corpus striatum of Nrf2 (-/-) mice and in silico	Antioxidant therapy	[39]
circDLGAP4	miR-134-5p/CREB	Reduces OxS	PD	SH-SY5Y and MN9D cell lines and mouse model	Biomarker and antioxidative therapy	[41]
circzip-2	Zip2 miR-60-3p α-synuclein Daf-16 pathway	Reduces ROS production	PD	Transgenic C. elegans model of PD	Biomarker and antioxidative therapy	[42]
circFoxO3	FoxO3-BimEL pathway	Mediates glutamate-induced OxS	NDD	In vitro neuronal cell culture (HT22 cells)	Target for therapy	[43]
circRNA KIAA1586	hsa-miR-29b	Induces amyloid β protein	AD	In silico	Biomarker and therapeutic target	[44, 45]
CDR-1as	miR-7 α-synuclein protein	Mediates the initiation of OxS (suggested)	PD	Several studies	Target for therapy	[50, 54]
circRNA ZNF609	miR-615-metrorin (METRN) protein	Mediates the response to OxS	Retinal NDD	Muller cells and a rat model of retinopathy	Target for therapy	[52]
circRNA_008636	FoxO3 AMPK pathways	Mediates infection-induced OxS	CNS infection	Postoperative patients	A diagnostic marker for infection	[53]