Gut Immunity and Microbiota Dysbiosis Are Associated with Altered Bile Acid Metabolism in LPS-Challenged Piglets

<div>Hepatic gene expression related to enterohepatic circulation of bile acids by q-PCR. (a) Hepatic expression of genes that regulate bile acid metabolism. LRH-1: liver receptor homologue 1; FGFR4: fibroblast growth factor receptor 4; KLB: Klotho beta. (b) Hepatic expression of genes required for primary bile acid synthesis. CYP7A1: 7a-hydroxylase; CYP8B1: 12a-hydroxylase; CYP27A1: sterol 27-hydroxylase. (c) Expression of genes required for bile acid transportation. NTCP: Na<sup>+</sup>-taurocholate cotransporting polypeptide; OATP: organic anion transporting polypeptide; BSEP: bile salt export protein; MDR3: ATP binding cassette subfamily B member 4; MRP3: multidrug resistance-associated protein 3. <span class="nowrap"><svg height="10.7395pt" id="M39" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Gut Immunity and Microbiota Dysbiosis Are Associated with Altered Bile Acid Metabolism in LPS-Challenged Piglets 