Gut Immunity and Microbiota Dysbiosis Are Associated with Altered Bile Acid Metabolism in LPS-Challenged Piglets

Figure 6

The obstruction of bile acid enterohepatic circulation made against the normal lipid metabolism. (a) Ileal expression of genes that regulate lipolysis. LPL: lipoprotein lipase; Dbi: diazepam binding inhibitor; Fabp5: fatty acid-binding protein 5. (b) Ileal gene expression of fatty acid transporters. (c) Hepatic expression of genes related to fatty acid synthesis. FASN: fatty acid synthase; ACACA: acetyl-CoA carboxylase alpha; SREBF1: sterol regulatory element binding transcription factor 1. (d) Hepatic expression of genes required for fatty acid β-oxidation. Acsl1: acyl-CoA synthetase long-chain family member 1; Cpt1a: carnitine palmitoyltransferase 1a; PPAR-α: peroxisome proliferator-activated receptor alpha. (e) Hepatic gene expression of fatty acid transporters. , , , and were regarded as statistically significant.

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