Research Article
[Retracted] Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects
Figure 1
Effects of gintonin against Aβ-induced oxidative stress: (a, b) LPO and ROS assays in cells; (c, d) LPO and ROS assays in the frontal cortex and hippocampus; (e, f) immunofluorescence analysis for NRF-2 and HO-1 in the frontal cortex and hippocampus of the experimental mice; (g) western blot analysis for NRF-2, HO-1, p-AKT, and PARP-1 in the saline, Aβ, Aβ+gintonin, and gintonin-alone treatment groups. A significant difference between the Aβ- and saline-treated groups; #a significant difference from the Aβ+Gt-treated group. The data are presented as the mean (SD) of three independent experiments. #; ; , . Gt: gintonin; Aβ: amyloid-beta; DAPI: 4,6-diamidino-2-phenylindole; n: not significant.
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