[Retracted] The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases

Figure 3

The role of posttranscriptional modification of mitochondrial proteins in mitochondrial quality control. The quality control of mitochondria mainly includes fusion, fission, mitophagy, and biogenesis. Ubiquitination of the mitochondrial protein OMA1 promotes the fusion of healthy mitochondria. The ubiquitination of mitochondrial protein AKAP121 and the phosphorylation of Drp1 are conducive to the fission of normal mitochondria. Phosphorylation of mitochondrial protein PINK1 and SUMOylation of Drp1 induces mitophagy in unhealthy mitochondria.