RIPK3 Induces Cardiomyocyte Necroptosis via Inhibition of AMPK-Parkin-Mitophagy in Cardiac Remodelling after Myocardial Infarction

Figure 5

RIPK3 inactivated Parkin via inhibiting AMPK-mediated Parkin phosphorylation (). (a–c) Parkin and AMPK phosphorylation was analysed by western blots. AICAR (AI), the AMPK pathway activator, was used to activate AMPK pathways in WT cell under hypoxia injury. (d) The coimmunofluorescence of mitochondria and lysosomes in cardiomyocyte. AMPK activation facilitated the disassociation between the mitochondria and lysosome under hypoxia injury. Data are shown as the , .

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