2700 mg/day effervescent NAC (1800 mg in the morning, 900 evening, 6 months)
↑ by 23% brain GSH levels in the medial prefrontal cortex (i) Improvement in positive symptoms, cognition, level auditory processing, and white matter diffusion
[92] (double-blind randomized controlled pilot trial, autism)
Human
33 (31 males, 2 females, ages 3.2-10.7 years)
900 mg/day (4 weeks) → 900 mg/twice per day (4 weeks) → 900 mg/thrice per day (4 weeks) (oral)
(i) NAC groups presented significant improvements on ABC-irritability subscale (ii) Side effect: gastrointestinal