Follistatin-Like 1 Attenuation Suppresses Intervertebral Disc Degeneration in Mice through Interacting with TNF-α and Smad Signaling Pathway

Figure 6

Knockdown of FSTL-1 can reduce the TNF-α-mediated inflammatory response by inhibiting the expression of P-Smad1/5/8, P-P65, and P-Erk1/2. (a–d) Western blot analysis of P-Smad2/3, P-Smad1/5/8, P-P65, and P-Erk1/2 in nucleus pulposus cells at different time points after stimulation with 10 ng/ml TNF-α in WT and FSTL-1+/- mice.

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