Review Article
Oxidative Stress-Derived Mitochondrial Dysfunction in Chronic Obstructive Pulmonary Disease: A Concise Review
Table 1
Mitochondrial sources of ROS production.
| | Isopotential group | Enzyme | Site of production | Tissue/organ |
| | NADH/NAD+ | α-Ketoglutarate dehydrogenase (KDGH) | FAD | Liver, skeletal muscle | | Pyruvate dehydrogenase (PDH) | FAD | Liver, skeletal muscle | | Branched-chain keto acid dehydrogenase | FAD | Skeletal muscle | | 2-Oxoadipate dehydrogenase | FAD | Skeletal muscle | | Complex I | FMN | Cardiac muscle | | UQH2/UQ | Complex I | UQ binding site | Skeletal muscle | | Complex II | FAD | Skeletal muscle, cardiac muscle, liver | | Complex III | UQ binding site | Skeletal muscle, cardiac muscle, liver | | Electron transfer flavoprotein: ubiquinone oxidoreductase | FAD | Undetermined | | sn-Glycerol-3-phosphate dehydrogenase (3GPDH) | FAD | Skeletal muscle, cardiac muscle, liver | | Proline dehydrogenase | FAD | Undetermined | | Dihydroorotate dehydrogenase | FAD | Undetermined |
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NADH/NAD+: reduced nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide isopotential group; UQH2/UQ: ubiquinol/reduced ubiquinone isopotential group; FAD: flavin adenine dinucleotide.
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