Mitochondrial-Targeting Antioxidant SS-31 Suppresses Airway Inflammation and Oxidative Stress Induced by Cigarette Smoke

Figure 10

SS-31 suppresses CSE-induced oxidative stress via inhibition of MAPK signaling. (a) Intracellular ROS generation in BEAS-2B cells. (b–d) Activities of MDA (b), SOD (c), and GSH-Px (d) in cells ( per group). , , , and vs. control; ^## and ^### vs. ani+CSE; ^& and ^&&& vs. CSE; ^$$ and ani+SS-31+CSE vs. SS-31+CSE. Abbreviations: ani: anisomycin; CSE: cigarette smoke extract; GSH-Px: glutathione peroxidase; MDA: malondialdehyde; ROS: intracellular reactive oxygen species; SOD: superoxide dismutase.

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