Mitochondrial-Targeting Antioxidant SS-31 Suppresses Airway Inflammation and Oxidative Stress Induced by Cigarette Smoke

Figure 2

SS-31 attenuates CS-induced histologic changes in mouse lung. (a–d) H&E staining of mouse lung tissue from control () (a), CS () (b), SS-31 (L)+CS () (c), and SS-31 (H)+CS () (d) groups (200x magnification, scale ). (e) Inflammation scores of mouse lungs. Bottom images depict an enlarged view of boxed areas in corresponding top images; red box: peribronchiolar infiltrates; blue box: alveolar septal infiltrates; yellow box: perivascular infiltrates; green box: bronchus-associated lymphoid tissue hyperplasia. (f–i) Giemsa staining of mouse lung tissue from control (f), CS (g), SS-31 (L)+CS (h), and SS-31 (H)+CS (i) groups (600x magnification, scale ). Red arrow: neutrophils; black arrow: macrophages. vs. control; ^#### vs. CS; ^&& SS-31 (L)+CS vs. SS-31 (H)+CS. Abbreviations: CS: cigarette smoke; H&E: hematoxylin and eosin; SS-31 (H): high-dose SS-31 (5 mg/kg); SS-31 (L): low-dose SS-31 (2.5 mg/kg).

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