Mitochondrial-Targeting Antioxidant SS-31 Suppresses Airway Inflammation and Oxidative Stress Induced by Cigarette Smoke

Figure 7

RNA sequencing in mouse lung. (a) Clustering of DEGs in the CS and SS-31 (H)+CS groups ( per group). (b) GO analysis of DEGs. The figure is composed of 3 parts: molecular functions, cellular components, and biological processes. The significance level of enrichment was set as a corrected value < 0.05. (c) KEGG pathway analysis of DEGs. The bubble chart shows enrichment of DEGs in signaling pathways. The -axis label represents the pathway, and the -axis label represents the enrichment factor—i.e., the number of DEGs enriched in the pathway divided by the total number of genes in the background gene set. The size of each bubble represents the number of DEGs enriched in the pathway, and the color represents the significance of enrichment. Abbreviations: CS: cigarette smoke; DEG: differentially expressed gene; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; SS-31 (H): high-dose SS-31 (5 mg/kg).

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