Effects of Lipid Peroxidation-Mediated Ferroptosis on Severe Acute Pancreatitis-Induced Intestinal Barrier Injury and Bacterial Translocation

Figure 2

Ileum tissue was collected to detect iron content (a), MDA (b), GSH levels (c), and GPX4 activity (d) at different time points. In the SAP group, iron accumulated significantly, MDA content increased significantly, and GSH levels and GPx4 activity decreased. Lip-1 treatment decreased the iron and MDA content in intestines but markedly increased the GSH levels as well as GPX4 activity. All results are expressed as the (). The variables between groups were compared by Student’s -test and one-way ANOVA. and vs. the SO group; and vs. the SAP group.

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