Long Noncoding RNA ANPODRT Overexpression Protects Nucleus Pulposus Cells from Oxidative Stress and Apoptosis by Activating Keap1-Nrf2 Signaling

Figure 1

ANPODRT was downregulated in degenerative NP tissues and TBHP-stimulated NP cells. (a) The expression of ANPODRT from NP tissues of different degrees of IDD patients was analyzed by qRT-PCR. and versus Pfirrmann grade II group. (b) CCK-8 assay was used to determine the cytotoxic effects of TBHP on human NP cells by treating the cells with various concentrations of TBHP for durations of 24 h. (c) The expression of ANPODRT in human NP cells that treated with different TBHP concentrations for 24 h. (d) The expression of ANPODRT in human NP cells that treated with 45 μM TBHP for different time. Data are represented as the . , , and versus control group.

(a)

(b)

(c)

(d)