Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation

<div>Translocation of FOXO3 and p27 proteins from the cytoplasm to the nucleus in colorectal cancer cells treated with acetylshikonin. Nuclear fractional western blotting results of HCT-15 and LoVo cells treated with acetylshikonin (0, 1.25, 2.5, and 5 <i>μ</i>M). The protein levels of FOXO3 and p27 in the cytoplasm and nucleus were analyzed by western blotting using specific antibodies. GAPDH and Lamin A/C were used as loading control proteins for the cytoplasm and nucleus, respectively.</div>

Oxidative Medicine and Cellular Longevity

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Figure 9

Figure 9: Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation 

Figure 9 | Acetylshikonin Induces Apoptosis in Human Colorectal Cancer HCT-15 and LoVo Cells via Nuclear Translocation of FOXO3 and ROS Level Elevation 