The Secretome Deregulations in a Rat Model of Endotoxemic Shock

Figure 5

Protein-protein interaction network of (a) up and (b) downregulated proteins in the LPS T50 group and (c) up and (d) downregulated proteins in the LPS T90 groups. The study of proteins identified both in T50 (CT and LPS) and T90 (CT and LPS). The analyses using Gene Ontology (GO) databases revealed the most modified biological processes following the injection of LPS. STRING protein database was used to clustered deregulated proteins. The continuous lines represent protein interactions within the cluster, and the discontinuous lines represent protein interactions between different clusters.

(a) Upregulated protein at T50

(b) Downregulated protein at T50

(c) Upregulated protein at T90

(d) Downregulated protein at T90