Histone Methyltransferase G9a Promotes the Development of Renal Cancer through Epigenetic Silencing of Tumor Suppressor Gene SPINK5

Figure 1

Frequent upregulation of G9a in human RCC. (a) Through bioinformatics data mining, it was revealed that G9a was highly expressed in human renal cancer cell lines and clinical samples (no value means normal tissue). 1: G9a expression in different renal cell carcinomas; 2: G9a expression in different renal cell carcinoma cell lines; 3: G9a expression in clear renal cell carcinoma and normal tissue. (b) G9a expression was significantly upregulated in tumor tissues of most patients with RCC compared with adjacent tissues. (c) G9a expression in four patients was measured. (d) High expression of G9a was associated with poor prognosis of renal cancer (, ). (e) G9a expression was significantly upregulated in 3 renal cancer cell lines (786-O, SN12C, and OSRC-2) compared with human renal tubular epithelial cell line (HK-2).

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