Histone Methyltransferase G9a Promotes the Development of Renal Cancer through Epigenetic Silencing of Tumor Suppressor Gene SPINK5

Figure 3

Inhibition of methylation of G9a significantly inhibits migration and invasion of RCC cells. (a) Migratory abilities of 786-O cells were measured through wound healing assay after the addition of inhibitors. (b, c) Invasive abilities of 786-O cells were measured through transwell assay after the addition of inhibitors for 24 h. (d) Migratory abilities of SN12C cells were measured through wound healing assay after the addition of inhibitors. (e, f) Invasive abilities of SN12C cells were measured through transwell assay after the addition of inhibitors for 24 h. (g) The expression of protein-related EMT pathway was measured by western blot.

(a)

(b)

(c)

(d)

(e)

(f)

(g)