Hydrogen Sulfide in Skin Diseases: A Novel Mediator and Therapeutic Target

Figure 1

Production of H₂S in the skin. CBS catalyses the generation of cystathionine from the substrates homocysteine and serine and liberates H₂S from a combination of cysteine and homocysteine. CSE mainly converts cysteine into H₂S, pyruvate, and ammonia. 3-MST generates H₂S from 3-mercaptopyruvate produced by cysteine aminotransferase. CBS: cystathionine β-synthase; CSE: cystathionine γ-lyase; GSH: glutathione; 3-MST: 3-mercaptopyruvate sulfide transferase; CAT, cysteine aminotransferase.