Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation

Figure 1

Neferine attenuates acute HI brain damage in neonatal rats. (a) The brains were isolated from each group 24 h after HI brain injury. (b) The ratio of wet and dry is calculated in each group. and . . (c) Calculation of the infarct area shown by TTC staining. . . (d) Representative results of TTC-stained coronal brain sections 24 h after HI brain injury. (e) Representative images of TUNEL staining (green). The nucleus (blue) was labeled with DAPI 24 h after HI brain injury. Scale . . (f) Protein expression level of Bax and Bcl-2 24 h after HI brain injury. (g, h) Analyses of Bax and Bcl-2 (of β-actin). , , and . .

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