Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation

Figure 3

Neferine may reduce acute inflammation and oxidative stress after HIBD in neonatal rats. (a) The levels of mRNA expression in brain tissue 24 h after HI brain injury normalized to those of β-actin for each sample. , , , and versus the sham group. and versus the HI group. . (b) The SOD activity in the brain tissue 24 h after HI brain injury. and . . (c) The GSH-px level in brain tissue 24 h after HI brain injury. and . . (d) Representative immunofluorescence staining images of cleaved caspase-1 (green) and DAPI (blue) 24 h after HI. Scale .

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