Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway

Figure 2

MMP3 is predominantly expressed in BMVECs. (a) MMP3 mRNA abundance was evaluated via q-PCR in BMVECs and astrocytes isolated from the brains of WT (BMVEC-WT and Astrocyte-WT) and MMP3-KO (BMVEC-KO and Astrocyte-KO) mice; results were normalized to measurements in BMVEC-WT. , ^####. (b) MMP3 protein abundance was evaluated via ELISA in culture medium from the indicated cell populations. , ^####. (c) MMP3 mRNA abundance was evaluated in microvascular endothelial cells (MVECs) isolated from the brains, hearts, lungs, kidneys, and spleens of WT mice results were normalized to measurements in brain MVECs. .

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