Inactivation of TOPK Caused by Hyperglycemia Blocks Diabetic Heart Sensitivity to Sevoflurane Postconditioning by Impairing the PTEN/PI3K/Akt Signaling

<div>Myocardial TOPK (b), PTEN (c), and Akt (d) protein expression and their phosphorylation status after myocardial IR with or without SPostC in nondiabetic mice. IR+SPostC+LY and IR+SPostC+HI indicated mice pretreated with LY or HI, respectively, and then subjected to IR and SPostC. (a) Representation of western blots. Mean band density was normalized relative to GAPDH. The IR group was used as control and normalized to unity, and the protein expression of other groups was displayed as changes over this baseline. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Inactivation of TOPK Caused by Hyperglycemia Blocks Diabetic Heart Sensitivity to Sevoflurane Postconditioning by Impairing the PTEN/PI3K/Akt Signaling 

Figure 3 | Inactivation of TOPK Caused by Hyperglycemia Blocks Diabetic Heart Sensitivity to Sevoflurane Postconditioning by Impairing the PTEN/PI3K/Akt Signaling 