Qiangji Jianli Decoction Alleviates Hydrogen Peroxide-Induced Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics and Biogenesis in L6 Myoblasts

Figure 9

The possible mechanism of QJJLD. Excessive H₂O₂ caused the cellular ROS level increased, and MMP and ATP were reduced in L6 myoblasts. Administration of QJJLD significantly inhibited H₂O₂-induced imbalance of biogenesis and mitochondrial dynamics. QJJLD may alleviate mitochondrial dysfunction through the regulation of mitochondrial dynamics and biogenesis, the inhibition of ROS generation, and the promotion of mitochondrial energy metabolism. Therefore, QJJLD may have a beneficial effect on the therapy of muscle diseases associated with mitochondrial dysfunction.