The study was designed to assess the oxidative state of transplant patients with stable renal function; 67 stable kidney transplant patients treated with calcineurin inhibitors were studied.
Transplanted patients showed a higher oxidative status (MDA increase and GPx decrease) than healthy subjects. The oxidative status did not differ between the cyclosporine and tacrolimus cohorts.
The study was designed to determine the relationship between the presence of carotid artery lesions and oxidative parameters in 50 renal transplanted patients with stable renal function.
The serum GPx level among patients without atheroma plaques, calcification, or stenosis was higher than in those with ultrasound signs.
The study included 26 renal transplant patients, treated with a different combination of immunosuppressive agents: CyA-MMF-PRED-basiliximab and TAC-MMF-PRED-daclizumab. Plasma MDA levels were measured before transplantation and 1 and 6 months after TX.
Levels of MDA were increased before the transplantation in all renal patients. Immunosuppressive combined therapy with CyA was associated with the high values of MDA posttransplant. This study provides strong evidence that TAC is significantly associated with improved free radical metabolism.
AOPP and TAS were evaluated in transplanted patients on different calcineurin inhibitors. 35 patients were treated with CsA and 33 with TAC.
No significant differences in AOPP and TAS were found with respect to treatment. The only exception was the higher mean concentration of AOPP at month 1 in recipients treated with CsA.
The aim of this study was to compare the effect of immunosuppressive regimens using either mTORi or CNI on the risk of atherosclerosis in RARs. The study involved 24 RARs treated with mTORi and 20 RARs treated with immunosuppressive regimen based on CNI. Carotid atherosclerosis was evaluated by measurement IMT of the common and internal carotid artery walls and detection of carotid plaques by high-resolution ultrasonography. The study was performed 3-24 years after TX.
The mTORi group showed higher level of TC, LDL-C, and TG. Posttransplant diabetes developed in 34% of the mTORi group compared with 25% in the CNI group. There was no beneficial effect of immunosuppressive treatment with mTORi on carotid atherosclerosis in RARs.
The study was designed to evaluate whether or not CsA-free immunosuppressive regimen based on SRL prevents aortic stiffening and improves central hemodynamics in RARs. 44 patients enrolled in the trial were randomized at week 12 to continue CsA or switch to SRL, both associated with MMF. cSBP, cPP, AIx, and PWV: aortic stiffness was blindly assessed at W12, W26, and W52 together with ET-1, TBARS, and SOD and CT erythrocyte activities.
At W12, there was no difference between groups. At follow-up, PWV, cSBP, cPP, and AIx were lower in the SRL group. In parallel, ET-1 decreased in the SRL group, while TBARS, SOD, and CT erythrocyte activities increased in both groups but to a lesser extent in the SRL group. These results demonstrate that a CsA-free regimen based on SRL reduces aortic stiffness, ET-1, and oxidative stress in RARs suggesting a protective effect on the arterial wall that may be translated into cardiovascular risk reduction.
The study was designed to examine markers of lipid peroxidation and antioxidant potential in the blood (serum, plasma, and RBC) of 51 RARs and sex-matched volunteers as a control group (C). RARs were divided into two subgroups: RARs-A () were treated with triple-drug therapy including CsA and RARs-Z () were on double-drug regimen: PRED and AZA. We used several automated assays to estimate MDA, TRAP, GPx, GSH, SOD, CAT, vit. E, and lipid profiles.
Patients of RARs-A were found to have significantly elevated triglycerides, cholesterol-LDL, MDA, and TRAP and decreased activity of RBC glutathione peroxidase as compared with those of RARs-Z and group C. In conclusion, our data show that oxidative stress (with prooxidant effect of CsA partly at least), with reduced antioxidant potential of defense system, is associated with KTX.
The aim of the study was to analyze the relation between total antioxidant capacity and immunosuppressive therapies, renal function, and hematocrit in kidney transplant patients. The study included 46 adult patients following renal transplantation, treated with different combinations of immunosuppressive agents: with CsA () or TAC ().
There was a significantly negative correlation between TAOC and plasma creatinine and a positive correlation between TAOC and creatinine clearance or hematocrit in patients treated with TAC but not with CsA. Immunosuppressive therapy with CsA was associated with higher TAOC. Anemia can be an independent risk factor for an increase of oxidative stress. TAOC was positively associated with renal function in patients treated with TAC.
23 KTX patients were included in the study. MDA, plasma selenium (se), GSH-Px, SOD, EZn, and ECu levels were studied before and in the 1st, 3rd, 7th, 14th, and 28th days after TX. 11 recipients were treated with CsA whereas 12 patients were treated with TAC.
The GSH-Px, SOD, ECu, EZn, and selenium levels were lower and MDA levels were higher in patients than controls before TX. MDA levels decreased and SOD, GSH-Px, ECu, and EZn levels increased in parallel to the decrement of serum creatinine levels following KTX. No difference was found among the patients regarding the treatment regime. The study data suggest that the improvement in oxidative state parameters begins at the first day of KTX and continues at the 28th posttransplant day in living donor TX.
The objective of this study was to analyze the effect of converting from cyclosporine to tacrolimus on lipoprotein oxidation in renal transplant recipients. 12 recipients were studied treated with a CsA-MMF-PRED combination that was converted to TAC-MMF-PRED.
The conversion to TAC resulted in significant decrease in TC levels and produced a nonsignificant decrease in Ab-oxLDL. In renal TX, TAC therapy was associated with a better lipid profile and lower in vivo LDL oxidation when compared with CsA treatment.
