SS-31 Protects Liver from Ischemia-Reperfusion Injury via Modulating Macrophage Polarization

Figure 4

SS-31 inhibited the M1 polarization of KCs in the liver. (a) Representative immunofluorescence of iNOS (red) and F4/80 (green) in liver sections after IRI treated with or without SS-31 ( per group). (b) Levels of mRNAs encoding TNFα, iNOS, IL1β, and CCL2 (M1 markers) in KCs ( per group). (c) Levels of mRNAs encoding PMP22, KLF4, IrF4, and Mgl1 (M2 markers) in KCs ( per group). Scale bars, 20 μm. Data are , , , , and by unpaired Student’s -test.

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