Resveratrol Alleviates 27-Hydroxycholesterol-Induced Senescence in Nerve Cells and Affects Zebrafish Locomotor Behavior via Activation of SIRT1-Mediated STAT3 Signaling

Figure 6

Effects of REV on 27HC-induced locomotor disorders in zebrafish larvae. Zebrafish larvae from 36 hpf to 4 dpf were exposed to 20 μM 27HC, 10 nM E2, , or . CON group: ethanol treatment. (a) Locomotor behavior of zebrafish larvae was observed using EthoVision XT software Noldus IT. (b, c) Analysis of behavioral parameters of zebrafish larvae (). , statistically significant difference from the CON group. (b) . (c) . ^#, statistically significant difference from the 27HC-treated group. (b) , 27HC+NAC group; , 27HC+REV group. (c) , 27HC+NAC group; , 27HC+REV group. Data are expressed as the of three independent experiments. (d, e) qRT-PCR analysis of SIRT1 and IL-6. , statistically significant difference from the CON group (). (d) . (e) . ^#, statistically significant difference from the 27HC-treated group. (d) , 27HC+NAC group; , 27HC+REV group. (e) , 27HC+NAC group; , 27HC+REV group. Data are expressed as the of three independent experiments.

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