Resveratrol Alleviates 27-Hydroxycholesterol-Induced Senescence in Nerve Cells and Affects Zebrafish Locomotor Behavior via Activation of SIRT1-Mediated STAT3 Signaling

Figure 7

Schematic representation of molecular mechanisms involved in 27HC-induced senescence. 27HC induces a high level of ROS generation, which can downregulate the expression of SIRT1 and subsequently activate the phosphorylation and acetylation of STAT3, which is regulated by SIRT1. Activation of STAT3 triggers aging-related changes in inflammation and the cell cycle leading to neural cell senescence and organism aging.